Nivolumab and ISA 101 HPV vaccine in incurable HPV-16+ cancer

Prevalence of cervical infection with HPV type 16 and 18 in Vietnam: Implication for vaccine campaign Key words: Cervical cancer, Human papilloma virus, Vietnam, HPV 16, HPV 18, HPV vaccine Word count: 2200 words

HPV vaccine for cancer and wart prevention.

Evidence Three large international RCTs in females aged 15 to 26 used modified intention-to-treat analysis (including patients with positive test results for HPV at baseline) for all HPV lesions.1-4 • Quadrivalent vaccine (HPV 6, 11, 16, and 18): -FUTURE 1 trial1 following 5455 women for 4 years found decreased external genital lesions (3.8% vs 5.7% [placebo]; number needed to vaccinate [NNV] =...

HPV vaccine against HPV infection and disease in males.

BACKGROUND Infection with human papillomavirus (HPV) and diseases caused by HPV are common in boys and men. We report on the safety of a quadrivalent vaccine (active against HPV types 6, 11, 16, and 18) and on its efficacy in preventing the development of external genital lesions and anogenital HPV infection in boys and men. METHODS We enrolled 4065 healthy boys and men 16 to 26 years of age,...

HPV-16 RNA processing.

To understand human papillomavirus type 16 (HPV-16) gene regulation, it is necessary to understand HPV-16 RNA processing. HPV-16 encodes multiple 5'- and 3'-splice sites and two polyadenylation signals pAE and pAL (Figure 1). The major 3'-splice site on the HPV-16 genome (SA3358) is used for generation of E6, E7, E4, L1 and L2 mRNAs. It encodes a suboptimal splice signal but is under control of...

Elevated HPV-18 and HPV-16 DNA in the Plasma of Patients with Advanced Cervical Cancer

Every year, more than half a million women develop cervical cancer, half of whom may die eventually (Franceschi, 2005). Several studies have shown the major etiologic role of the human papilloma virus (HPV) infection in neoplasia of cutaneous and mucosal epithelia (Castle et al., 2005; Khan et al., 2005; Kjaer et al., 2006). HPV infection is a common sexually transmitted contamination and both ...